Antisense Antibacterials: From Proof-Of-Concept to Therapeutic Perspectives
نویسندگان
چکیده
Recent years have witnessed several gram-negative bacteria (GNB) species and a few grampositive bacteria (especially the Staphylococcus aureus) posing overwhelming threats to the healthcare-associated infections as a series of frightening superbugs (Engel, 2010; Peleg & Hooper, 2010). It is primarily due to the fact that incidence of multidrug resistance (MDR) or pan-drug resistance (PDR) bacteria have been escalating in a manner of global dimension, frequent prevalence and alarming magnitude. The predominate resistance issues are those related to GNB species, including Enterobacteriaceae (Deshpande & et al, 2010), Klebsiella pneumonia, Pseudomonas aeruginosa and Acinetobacter baumannii. Theses circulating isolates have created big problems for treatment of nosocomial infection because they carry highly transmissible elements encoding multiple resistance genes, e.g. extended-spectrum betalactamases (ESBLs) that inactivates different classes of first-line antibiotics (Bush, 2010; Engel, 2010), metallo-beta lactamase that hydrolyzes penicillins, cephalosporins and carbapenems, efflux pumps that decrease bacterial transporting ability to almost all antibiotics and natural antimicrobial products (Pages & et al, 2010), and promoters that ensure the transcription of these genes.
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